Brain-associated inhibitor of tissue-type plasminogen activator
AssigneesAmerican Red Cross, Human Genome Sciences, Inc.
InventorsGregg A. Hastings, Timothy A. Coleman, Daniel A. Lawrence, Patrick J. Dillon
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Abstract
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system-related disorders and therapeutic methods for treating nervous system-related disorders.
Claims49
An isolated protein comprising a polypeptide sequence selected from the group consisting of:
- (a) amino acid residues 1 to 410 of SEQ ID NO:2;
- (b) amino acid residues 2 to 410 of SEQ ID NO:2;
- (c) amino acid residues 19 to 410 of SEQ ID NO:2;
- (d) amino acid residues 20 to 410 of SEQ ID NO:2;
- and
- (e) amino acid residues 21 to 410 of SEQ ID NO:2.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length polypeptide, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97722;
- (b) the amino acid sequence of the full-length polypeptide, excluding the N-terminal methionine residue, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97722;
- and
- (c) the amino acid sequence of the mature polypeptide, which amino acid sequence is encoded by the cDNA clone contained in ATCC Deposit No. 97722.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues n to 410 of SEQ ID NO:2, where n is an integer in the range of 1 to 49;
- (b) amino acid residues 1 to m of SEQ ID NO:2, where m is an integer in the range of 381-409;
- and
- (c) amino acid residues n to m of SEQ ID NO:2, where n is an integer in the range of 1 to 49 and m is an integer in the range of 381-409.
An isolated protein comprising an amino acid sequence selected from the group consisting of
- (a) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 97722 wherein said portion excludes up to 48 amino acid residues from the amino terminus of said complete amino acid sequence;
- (b) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 97722 wherein said portion excludes up to 30 amino acid residues from the C-terminus of said complete amino acid sequence;
- and
- (c) a portion of the complete amino acid sequence encoded by the cDNA clone contained in ATCC Deposit 97722 wherein said portion excludes up to 48 amino acid residues from the amino terminus and up to 30 amino acids from the C-terminus of said complete amino acid sequence.
Dependencies are inferred from the claim text.