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US 6,191,256 B1Granted
Recombinant factor VIII binding peptides
AssigneeBayer Aktiengesellschaft
InventorsLi Ang Chen, Joseph A. Buettner, Ruben G. Carbonell
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Abstract
Peptides that have domains that bind to recombinant factor VIII (rFVIII) are disclosed. A method of rFVIII binding assay using the peptides deduced from a combinatorial library in a filtration plate process is described. A method of using peptides having these available binding domains in an affinity chromatography process to purify factor VIII is also taught.
Claims3
A composition comprising a peptide having an available rFVIII binding domain, wherein the binding domain is selected from the group consisting of Arg Asn Pro Pro Asn Asn;
- Tyr Val Gln Gly Leu Trp;
- Phe Arg Pro His Trp Ala;
- His Tyr Trp Phe Tyr Lys;
- Ile Arg Phe Tyr Ser Glu;
- Asn Ala Ile Phe Gln Trp;
- Gln Arg Leu Ile Gln Phe;
- Lys Ala Gln Glu Thr Trp;
- and Glu Pro Arg Val Ile Gly (SEQ ID NOS:
- 2-4, 6, 7, and 11-14, respectively).
6 more elements
Dependencies are inferred from the claim text.