Antimicrobial cationic peptides
AssigneeThe University of British Columbia
InventorsTimothy J. Falla, Robert E. W. Hancock, Monisha Gough
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AssigneeThe University of British Columbia
InventorsTimothy J. Falla, Robert E. W. Hancock, Monisha Gough
Estimating the term…
A novel class of cationic peptides having antimicrobial activity is disclosed. These peptides can be encompassed by the formulas: X1X1PX2X3X2P(X2X2P)nX2X3(X5)o; (SEQ ID NO: 23) X1X1PX2X3X4(X5)rPX2X3X3; (SEQ ID NO: 24) X1X1X3(PW)uX3X2X5X2X2X5X2(X5)o; and (SEQ ID NO: 25) X1X1X3X3X2P(X2X2P)nX2(X5)m; (SEQ ID NO: 26) wherein: m is 1 to 5; n is 1 or 2; o is 2 to 5; r is 0 to 8; u is 0 or 1; X1 is Isoleucine, Leucine, Valine, Phenylalanine, Tyrosine, Tryptophan or Methionine; X2 represents Tryptophan or Phenylalanine X3 represents Arginine or Lysine; X4 represents Tryptophan or Lysine; and X5 represents Phenylalanine, Tryptophan, Arginine, Lysine, or Proline. The invention also provides a method of producing a cationic peptide variant having antimicrobial activity.
An isolated cationic peptide selected from the group consisting of:
An isolated cationic peptide selected from the group consisting of:
An isolated cationic peptide consisting of an amino acid sequence selected from the group consisting of:
An isolated cationic peptide having an amino acid sequence selected from the group consisting of:
Dependencies are inferred from the claim text.