Para-aminomethylaryl carboxamide derivatives

A compound of formula Ia:

• wherein
• X is
• 1) a bond, or
• 2) C(R7)(R8);
• L is
• 1) —S(O)2;
• R1 is
• 1) Cy, or
• 2) Cy-C1-10alkyl,
• wherein alkyl is optionally substituted with one to four substituents independently selected from Ra;
• and Cy is optionally substituted with one to four substituents independently selected from Rb;
• or
• R1-L is
• 4-[N′-(2-methylphenyl)ureido]phenylacetyl;
• R2 is
• 1) H or
• 2) C1-5alkyl;
• R4 is
• 1) H or
• 2) C1-5alkyl;
• R5 is
• 1) C1-10alkyl,
• 2) Cy-(Cy1)p,
• 3) Cy-(Cy1)p-C1-10alkyl,
• wherein alkyl is optionally substituted with one to four substituents independently selected from Ra;
• and Cy and Cy1 are optionally substituted with one to four substituents independently selected from Rb;
• R7 is
• 1) hydrogen, or
• 2) C1-3alkyl;
• R8 is
• 1) hydrogen;
• Ra is
• 1) —CF3;
• 2) —ORd,
• 3) —NO2,
• 4) halogen
• 5) —S(O)mRd,
• 6) —CRd(N—ORe),
• 7) —S(O)2ORd,
• 8) —S(O)mNRdRe,
• 9) —NRdRe,
• 10) —O(CRfRg)nNRdRe,
• 11) —C(O)Rd,
• 12) —CO2Rd,
• 13) —CO2(CRfRg)nCONRdRe,
• 14) —OC(O)Rd,
• 15) —CN,
• 16) —C(O)NRdRe,
• 17) —NRdC(O)Re,
• 18) —OC(O)NRdRe,
• 19) —NRdC(O)ORe, or
• 20) —NRdC(O)NRdRe;
• Rb is
• 1) a group selected from Ra,
• 2) C1-10 alkyl,
• 3) C2-10 alkenyl,
• 4) C2-10 alkynyl,
• 5) Cy, or
• 6) Cy-C1-10 alkyl,
• wherein alkyl, alkenyl, alkynyl, and Cy are optionally substituted with a group independently selected from Rc;
• substituted with a group independently selected from Rc;
• Rc is
• 1) halogen,
• 2) amino,
• 3) carboxy,
• 4) C1-4alkyl,
• 5) C1-4alkoxy,
• 6) aryl,
• 7) aryl C1-4alkyl, or
• 8) aryloxy;
• Rd and Re are independently selected from the group consisting of
• 1) hydrogen,
• 2) C1-10alkyl,
• 3) C2-10alkenyl,
• 4) C2-10alkynyl,
• 5) Cy, and
• 6) Cy C1-10alkyl,
• wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from Rc;
• Rf and Rg are independently selected from hydrogen, C1-10alkyl, Cy and Cy C1-10alkyl;
• Rba is
• 1) halogen,
• 2) C1-3alkyl, or
• 3) C1-3alkoxy;
• Cy and Cy1 are independently cycloalkyl or aryl;
• m 0, 1 or 2;
• n integer from 1 to 10;
• p is 0 or 1;
• or
• a pharmaceutically acceptable salt thereof.