Human leukocyte 12-lipoxygenase and its role in the pathogenesis of disease states
AssigneeCity of Hope
InventorsJerry L. Nadler, Rama Natarajan
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Abstract
The present invention relates to a method for inhibiting the etiology of disease in patients having a disease state caused by an excess of 12-lipoxygenase or its products. In particular, the invention provides for administration of a human leukocyte 12-lipoxygenase pathway inhibitor to inhibit disease etiology, to inhibit the proliferation of breast cancer and to increase insulin receptor phosphorylation in a patient having Type II diabetics.
Claims15
A method for inhibiting the etiology of disease in a human patient suffering from or at risk for a disease state in which hl 12-lipoxygenase or 12-HETE is an etiological agent which comprises administering to said human patient a hl 12-lipoxygenase pathway inhibitor in an amount effective to retard or inhibit the expression or activity of said hl 12-lipoxygenase;
- provided that said hl 12-lipoxygenase pathway inhibitor is not aminoguanidine or pioglitazone.
A method for inhibiting the proliferation of breast cancer tissue in a human patient which comprises administering to said patient a therapeutically effective amount of a drug which inhibits hl 12-lipoxygenase expression or activation;
- provided that said hl 12-lipoxygenase inhibitor is not aminoguanidine or pioglitazone.
A method for mediating breast cancer cell growth and development which comprises administering to a patient in need thereof a therapeutically effective amount of a hl 12-lipoxygenase pathway inhibitor;
- provided that said hl 12-lipoxygenase pathway inhibitor is not aminoguanidine or pioglitazone.
A method for inhibiting the etiology of disease in a patient having a disease state in which 12-HETE is an etiological agent which comprises administering a hl 12-lipoxygenase pathway inhibitor which decreases mitogenic activity in said patient;
- provided that said hl 12-lipoxygenase pathway inhibitor is not aminoguanidine or pioglitazone.
A method for increasing insulin receptor phosphorylation in a patient having Type II diabetes which comprises administering to the patient a therapeutically effective amount of a hl 12-lipoxygenase pathway inhibitor sufficient to inhibit hl 12-lipoxygenase pathway products from inhibiting insulin receptor phosphorylation;
- provided that said hl 12-lipoxygenase pathway inhibitor is not aminoguanidine or pioglitazone.
Dependencies are inferred from the claim text.