Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them

A chroman of formula I:

• wherein:
• R(1) and R(2) each independently of one another is hydrogen CpF2p+1, having 1, 2, 3, 4, 5 or 6 carbon atoms, or phenyl, which is unsubstituted or substituted by 1 or 2 substituents selected from F, Cl, Br, I, —CF3, methyl, methoxy, sulfamoyl, methylsulfonylamino or methylsulfonyl;
• p is 1, 2, or 3;
• or
• R(1) and R(2) together are an alkylene chain having 2, 3, 4, 5, 6, 7, 8, 9, or 10 carbon atoms;
• R(3) is R(9)—CnH2n[NR(11)]m—;
• R(9) is hydrogen or cycloalkyl having 3, 4, 5, 6, 7, or 8 carbon atoms;
• n is zero, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10;
• m is zero or 1;
• R(11) is hydrogen or alkyl having 1, 2, 3, 4, 5, or 6 carbon atoms;
• or
• R(11), together with R(9), is an alkylene group having 1, 2, 3, 4, 5, 6, 7, or 8 carbon atoms;
• where one CH2 group of the group CnH2n is optionally replaced by —O—, —SOq—, or —NR(10)—;
• q is zero, 1, or 2;
• R(10) is hydrogen, methyl, or ethyl;
• R(4) is R(12)—CrH2r—;
• R(12) is hydrogen, cycloalkyl having 3, 4, 5, 6, 7, or 8 carbon atoms, piperidyl, 1-pyrrolidinyl, N-morpholino, N-methylpiperazino, —CpF2p+1 pyridyl, thienyl, imidazolyl, or phenyl, which is unsubstituted or substituted by 1 or 2 substituents selected from F, Cl, Br, I, —CF3m methyl, methoxy, sulfamoyl, methylsulfonyl or methylsulfonylamino;
• r is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 ,17, 18, 19, or 20;
• where once CH2 group of the group C2H2r can be replaced by —O—, —C═C—, —C≡C—, —CO—, —CO—O—, —SOq— or —NR(10)—;
• q is zero, 1 or 2;
• R(10) is hydrogen, methyl, or ethyl;
• R(5), R(6), R(7), and R(8) each independently of one another is hydrogen, F, Cl, Br, I, alkyl having 1, 2, 3, or 4 carbon atoms, cycloalkyl having 3, 4, 5, 6, 7, or 8 carbon atoms, —CN, —CF3, —C2F5, —C3F7, —N3, —NO2, —CONR(13)R(14), —COOR(15), R(16)—CsH2s—Y—, or phenyl, which is unsubstituted or substituted by 1 or 2 substituents selected from F, Cl, Br, I, —CF3, methyl, methoxy, sulfamoyl or methylsulfonyl;
• R(13) and R(14) each independently of one another is hydrogen or alkyl having 1, 2 or 3 carbon atoms;
• R(15) is hydrogen, methyl, ethyl, phenyl, or —CuH2u—NR(13)R(14);
• u is 2 or 3;
• R(16) is hydrogen, cycloalkyl having 3, 4, 5, 6, 7, or 8 carbon atoms, —COOR(15), thienyl, imidazolyl, pyridyl, quinolyl, isoquinolyl, piperidyl, 1-pyrrolidinyl, N-morpholino, N-methylpiperazino, —CtF2t+1, or phenyl, which is unsubstituted or substituted by 1 or 2 substituents selected from F, Cl, Br, I, —CH3, methyl, methoxy, sulfamoyl or methylsulfonyl;
• s is zero, 1, 2, 3, 4, 5 or 6;
• t is 1, 2 or 3;
• Y is —SOq—, —CO—, —SO2—NR(10)—, —O—, NR(10)—, or —CO—NR(10);
• wherein R(6) is other than —OCF3 or —OC2F5;
• or a physiologically tolerable salt thereof.