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US 6,191,157 B1Granted
Hetero-linked phenylglycinolamides
AssigneeBayer Aktiengesellschaft
InventorsSiegfried Goldmann, Ulrich Müller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Rudi Grützmann, Martin Beuck
Life of this patent
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Abstract
The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.
Claims6
A hetero-linked phenylglycinolamide of the formula (I):
- in which
- A represents imidazolyl or benzimidazolyl, each of which is optionally substituted, optionally also via a nitrogen atom thereof, by 1 to 3 substituents independently selected from the group consisting of:
- a) halogen,
- b) trifluoromethyl,
- c) carboxyl,
- d) hydroxyl,
- e) nitro,
- f) cycloalkyl having 3 to 7 carbon atoms,
- g) benzyl,
- h) phenyl,
- i) benzyloxy,
- j) straight-chain or branched alkyl having up to 6 carbon atoms,
- k) straight-chained or branched alkoxy having up to 6 carbon atoms;
- or
- l) straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms,
- D represents an oxygen atom or a radical of the formula
- —CO—, —(CO)a—NR7, —(CH2)bS—, —(CH2)c—NR8 or —CH═CH—,
- in which
- a, b and c are identical or different and denote a number 0 or 1,
- R7 and R8 are identical or different and denote hydrogen, straight-chain or branched alkyl or acyl each having up to 6 carbon atoms, phenyl or benzyl, the phenyl or benzyl optionally being substituted up to 2 times identically or differently by nitro, halogen, trifluoromethyl or by straight-chain or branched alkyl or alkoxy each having up to 3 carbon atoms,
- E and L are identical or different and represents hydrogen, cycloalkyl having 3 to 8 carbon atoms, azido, hydroxyl, halogen, straight-chain or branched alkyl, alkoxy or alkenyl each having up to 6 carbon atoms,
- R1 represents cycloalkyl having 3 to 8 carbon atoms, or represents straight-chain or branched alkyl having up to 10 carbon atoms,
- R2 represents hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms,
- R3 represents a radical of the formula
- in which
- R9 denotes hydrogen or a radical of the formula CH2—OH,
- R10 denotes phenyl which is optionally substituted up to 3 times identically or differently by hydroxyl, halogen or straight-chain or branched alkyl having up to 5 carbon atoms,
- or a salt thereof.
25 more elements
Dependencies are inferred from the claim text.