Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
AssigneeCase Western Reserve University
InventorsGary Landreth, Colin Combs, Jerry Silver, Michael T. Fitch
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Abstract
The present invention relates to methods and compositions for treating Alzheimer's disease and other diseases and conditions with an inflammatory component (e.g., central nervous system injury). In particular, the present invention provides agents that regulate the production of proinflammatory and neurotoxic products involved in Alzheimer's disease and other diseases and conditions with an inflammatory component.
Claims18
A method for treating Alzheimer's disease, comprising administering a therapeutically effective amount of at least one PPARγ agonist to a subject, wherein said PPARγ agonist is selected from the group consisting of troglitazone, ciglitazone, pioglitazone, BRL 49653, and englitazone.
A method for treating a central nervous system injury, comprising administering a therapeutically effective amount of at least one PPARγ agonist to a subject suffering from a central nervous system injury, wherein said PPARγ agonist is selected from the group consisting of troglitazone, ciglitazone, pioglitazone, BRL 49653, and englitazone.
Dependencies are inferred from the claim text.