2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the C.N.S. and the heart

A 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivative of the formula

• wherein
• R1 represents a hydrogen atom, a C1-4 alkyl group or a phenyl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halo atom, a hydroxy group, a nitro group, a C1-4 alkoxy group, a (C1-4 alkyl)amino group and a di(C1-4 alkyl)amino group;
• or a group of the formula
• wherein
• Z stands for a hydrogen atom or a C1-4 alkoxy group,
• R0 means a group of the formula Alk-NR4R5 wherein
• Alk is a C1-6 straight or branched chain alkylene group,
• R4 and R5 represent, independently, a hydrogen atom, a C2-6 alkenyl group, a C1-8 alkyl group optionally substituted by a substituent selected from the group consisting of a hydroxy group, a (C1-4 alkyl)amino group, a di(C1-4 alkyl)amino group, a phenyl group—wherein the latter can be substituted by 1 to 3 C1-4 alkoxy group(s)—and a 5- or 6-membered saturated heterocyclic group containing one or more nitrogen atom(s) or a nitrogen and an oxygen atom and being linked through its nitrogen atom, said heterocyclic group being optionally substituted by a C1-4 alkyl group, or
• R4 and R5 form together with the adjacent nitrogen atom and optionally with one or more further nitrogen and/or oxygen and/or sulfur atom(s) a 5- to 10-membered saturated heterocyclic group optionally substituted by a C1-4 alkyl group or a phenyl group which latter is optionally substituted by a C1-4 alkoxy group,
• one of R2 and R3 is an amino group, while the other stands for an amino group or a 5- to 10-membered saturated heterocyclic group containing one or more nitrogen and/or oxygen and/or sulfur atom(s) and being linked through its nitrogen atom, said heterocyclic group being optionally substituted by a C1-4 alkyl group, a phenyl group or a halophenyl group, or the latter one of R2 and R3 means a group of the formula —SR wherein
• R represents a C1-8 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group, wherein the alkyl group is optionally substituted by a phenyl group or a halophenyl group,
• and optionally one or both amino group(s) is/are substituted by 1 or 2 substituent(s) selected from the group consisting of a C1-6 alkyl group, a C2-6 alkenyl group, a phenyl(C1-4 alkyl) group or a halophenyl-(C1-4 alkyl) group,
• and pharmaceutically acceptable acid addition salts thereof.