Heterocyclic derivative and medicine

A pharmaceutical composition for the treatment of cerebrovascular disease which comprises a compound of the following formula or a salt thereof, or a solvate thereof, as an active ingredient;

• wherein R1 represents an aryl group that may be substituted or 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 1-isoquinolyl, 4-isoquinolyl, 2-quinazolinyl or 1-methyl-2-indolyl that may be substituted;
• said aryl group and said 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 2-pyrimidiniyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 4-pyridazinyl, 1-isoquinoyl, 4-isoquinolyl, 2-quinazolinyl or 1-methyl-2-indolyl that may be respectively substituted by 1-3 substituents, whether the same or different, as selected from the group consisting of hydroxy, halogen, alkyl, haloalkyl, hydroxyalkyl, aralkyl, alkenyl, alkoxy, haloalkyloxy, alkylthio, cycloalkyl, cycloalkylalkyl, cycloalkyloxy, alkylsulfonyl, sulfamoyl, alkanoyl, amino, monoalkylamino, dialkylamino, carboxy, alkoxycarbonyl, cyano, and nitro;
• R2 represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino, or phenyl that may be substituted by 1-3 same or different substituents selected from the group consisting of halogen, alkyl, and alkoxy;
• R3 and R4 may be the same or different and each represents hydrogen or alkyl that may be substituted by one or more substituents selected from the group consisting of hydroxy, alkoxy, amino, monoalkylamino, and dialkylamino, or R3 and R4 taken together with the adjacent N atom represent a 4- through 8-membered cyclic amino group of the formula NR3R4, which may have N, O, or S in addition to said N atom as a ring member and may be substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, hydroxy, oxo, amino, monoalkylamino, dialkylamino, aryl that may be substituted, and pyridyl that may be substituted;
• A represents alkylene of 2-10 carbon atoms, which may be substituted by 1 or 2 same or different substituents selected from the group consisting of alkoxy, and oxo in optional substitutable positions;
• E represents O or S;
• W represents a single bond, O, S, or (CH2)n, where CH2 may be substituted by alkyl;
• n is an integer of 1 or 2;
• one of X, Y or Z is N or N→O and the remaining two are CH, or CR (where R represents alkyl);
• thus, ring G represents pyridine or its N-oxide.