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US 6,191,146 B1Granted
Hemoregulatory compounds
AssigneesSmithKline Beecham Corporation, Nycomed Austria GmbH
InventorsPradip Kumar Bhatnagar, Dirk Andries Heerding, James Francis Callahan, Michael Hartmann, Johann Hiebl, Peter Kremminger, Franz Rovenszky
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
Claims6
A compound of formula (I)
- Wherein:
- A1 and A2 are independently Z—(CH2)k—(NR′)m—;
- Z is pyridyl, and wherein the ring is substituted or unsubstituted by one or two C1-4alkyl, F, Cl, Br, I, C1-4 alkoxy, (CH2)mR4, oxo, oxime, O—C1-4alkyloxime, hydroxy, N(R3)2, acylamino or aminoacyl groups;
- R′ and R″ are independently hydrogen, C1-4alkylC(O)R4, C1-4alkyl or R′ and R″ are benzyl which is optionally substituted by one or two C1-4alkyl, C1-4alkoxy, F, Cl, I, Br, OH, or N(R3)2;
- k is independently an integer from 0 to 4;
- m is independently zero or one;
- Q is bicyclo[3.3.0]octanyl, xyleyl, benzophenonyl or 1,2,3,4-tetrahydronapthalyl;
- all of which are unsubstituted or substituted by one or more C1-4alkyl, C1-4alkoxy, halogen, mono or di C1-4alkylamino, (C1-4alkyl)2—NC(O)—, —(CH2)n—R2, —(CH2)n—R3, —(CH2)n—COR2 or —(CH2)n—COR3;
- R2 is independently —OR3, —NR32, —SR3;
- R3 is independently hydrogen, C1-4alkyl or benzyl;
- R4 is independently —OR3, —N(R3)2, —SR3;
- an
- n is independently an integer from 0 to 4;
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.