US 6,191,144 B1 · Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis

Abstract

The present invention is directed to the use of a group of ACE inhibitors to stimulate angiogenesis in mammals or in mammalian tissue in vitro. Specifically, the present invention is directed to inducing or enhancing angiogenesis through the administration of a group of ACE inhibitors and to ACE inhibitor-containing compositions for effecting the inducement or enhancement of angiogenesis. The ACE inhibitors may also be useful in the promotion of angiogenesis, such as in the promotion of wound healing, bone healing, and in the treatment of bums, as well as in promoting the formation, maintenance, and repair of tissue. In a preferred embodiment, the ACE inhibitor, quinapril, or quinaprilat, is used to treat, prophalactically or otherwise, mammals in need of angiogenic-treatment.

Claims17

Dependent claims

A method of stimulating angiogenesis in a mammal, which method comprises administering to a mammal in need thereof at least one ACE inhibitor conforming to the general formula:

wherein A is absent, a fused 5-, 6-, or 7-membered cycloaliphatic ring or a fused benzene ring which is unsubstituted or substituted by 1 or 2 alkoxy groups having 1 to 4 carbon atoms;
n is 0 or 1, and R is hydrogen or alkyl having 1 to 5 carbon atoms;
in an amount effective to stimulate angiogenesis.

Dependencies are inferred from the claim text.

Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis

Life of this patent

Method of using angiotensin converting enzyme inhibitor to stimulate angiogenesis

Life of this patent

Abstract

Claims17