Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
AssigneePharmacia & Upjohn Company
InventorsJeffrey L. Watts, Randall G. Stehle
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Abstract
The present invention provides a method of topically administering antimicrobial agents such as premafloxacin, premafloxacin-like compound, premafloxacin ester, ciprofloxacin, enrofloxacin, cefquinome, cefpodoxime, gentamicin or erythromycin for the treatment of systemic bacterial diseases in mammals.
Claims8
A method of treating a systemic bacterial disease in a mammal in need thereof which comprises topically applying to said mammal an effective amount of an antimicrobial agent in a propylene glycol/hexahydro-1-dodecyl-2H-azepin-2-one (PG/Azone) carrier wherein said antimicrobial agent is selected from the group consisting of premafloxacin or a premafloxacin ester wherein PG and Azone is in a ratio at least about 80% of propylene glycol by volume.
A method of treating a systemic bacterial disease in a mammal in need thereof which comprises topically applying to said mammal an effective amount of an antimicrobial agent in a propylene glycol/hexahydro-1-dodecyl-2H-azepin-2-one (PG/Azone) carrier wherein said antimicrobial agent is a compound of formula III or a pharmaceutically acceptable salt thereof
- wherein R1 is ethyl, cyclopropyl, or 2,4-difluorophenyl;
- R2 is hydrogen or C1-4 alkyl R3 is hydrogen, amino, or methyl;
- R4 and R5 are each independently hydrogen or methyl wherein PG and Azone is in a ratio at least about 80% of propylene glycol by volume.
Dependencies are inferred from the claim text.