Pyrano, piperidino, and thiopyrano compounds and methods of use

A compound having formula I

• or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein
• n is 0-1;
• m is 1-2;
• A is selected from the group consisting of NR2, O, and S;
• A′ is selected from the group consisting of NR3, O, S and CR4R5;
• D is selected from the group consisting of CH2 and C(O);
• D′ is selected from the group consisting of CH2, C(O), S(O), and S(O)2;
• R1 is selected from the group consisting of aryl and heterocycle;
• R2 and R3 are independently selected from the group consisting of hydrogen, alkoxyalkyl, alkyl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocyclealkyl, hydroxy, hydroxyalkyl, —NZ1Z2, and (NZ1Z2)alkyl wherein A1 and Z2 are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, aryl, arylalkyl, and formyl;
• R4 and R5 are independently selected from the group consisting of hydrogen and alkyl;
• R6 and R7 are independently selected from the group consisting of hydrogen and alkyl;
• with the proviso that when D is CH2 then D′ is other than CH2;
• and
• with the proviso that when D′ is S(O) or S(O)2 then A′ is CR4R5.