Methods for treatment of disorders of cardiac contractility
AssigneeThe Johns Hopkins University
InventorEduardo Marban
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Abstract
The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and cardiac performance, and methods for treatment of heart failure and other disorders associated with cardiac contractility by administration of one or more xanthine oxidase inhibitor compounds.
Claims34
A method of increasing calcium sensitivity of cardiac muscle, comprising selecting a mammal in need of increased cardiac sensitivity and administering to mammalian cardiac muscle of the maimnal an effective amount of a xanthine oxidase compound.
Dependencies are inferred from the claim text.