Amide derivatives of substituted quinoxaline 2, 3-diones as glutamate receptor antagonists

A compound of Formula I

• wherein
• R is
• attached at N to the quinoxaline ring through —(CH2)n— at the b-position,
• X is methyl;
• Y is alkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, selected from the group consisting of 2- or 3-benzfuryl, 2- or 3-indolyl, 2- or 3-furanyl, 2- or 3- thienyl 2-, 3-, 4-, 5-, 6-, or 7-benzothienyl, aralkyl, aryl, heterocycloalkyl selected from the group consisting of 2- or 3-pyrrolidinyl, 2- or 3-tetrahydrofuranyl, and 2-, 3-, or 4-piperidinyl;
• or is —(CH)p(R24)C(O)NR25R26 wherein p is an integer of from 1 to 6, R24 is hydrogen and R25 and R26 are each independently hydrogen, alkyl;
• or is —(CH2)q—R27 wherein q is an integer from 1 to 3 and R27 is a 4- to 7-membered heterocycle containing from one to four heteroatoms selected from oxygen, sulfur, and nitrogen, wherein said heterocycle is heterocycloalkyl selected from 2- or 3-pyrrolidinyl, 2- or 3-tetrahydrofuranyl, and 2-, 3-, or 4-piperidinyl, or heteroaryl selected from oxazolyl, oxadiazolyl, thiazolyl, 1,3,4-oxadiazolyl, 1,2,4-triazolyl, 1,3,4-thiadiazolyl, pyrrazolyl, imidazolyl, tetrazolyl, 1,3-oxazolyl, isoxazolyl, 1,2,3-triazolyl, 1,3,4-thiazolyl, or is —NR27a—R27b wherein 27a is hydrogen or alkyl, and 27b is as described in R27;
• n is 1;
• R1 is hydrogen;
• R2 is hydrogen;
• R3 is hydrogen:
• R4 is nitro, and
• R5 is methyl and is at the a-position.