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US 6,191,123 B1Granted
Organic-arsenic compounds
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Xing-Ping Liu
Life of this patent
Estimating the term…
Abstract
Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.
Claims17
A compound of the formula
- wherein R is
- R1 is H, NR3R4, SR3, OR3, in which R3 and R4 are each independently hydrogen or a C1-C4 alkyl group;
- X is C;
- R2 is H, NR3R4, SR3, OR3, or a group capable of bonding with X to form a fused substituted or unsubstituted benzene ring, or a fused imidazole ring,
- or a pharmaceutically acceptable salt thereof.
2 more elements
A compound selected from the group 4-(2′-Phenyl arsenic acid)-amino-6,7-dimethoxyquinazoline, 4-(4′-Phenyl arsenic acid)-amino-6,7-dimethoxyquinazoline, 2-Methylthio-4-(4′-phenyl arsenic acid)-aminopyrimidine, and 2-Methylthio-4-(2′-phenyl arsenic acid)-aminopyrimidine.
Dependencies are inferred from the claim text.