Erythromycin A derivatives

An erythrornycin A derivative represented by Formula (I):

• wherein n is an integer of from 1 to 4, R1 is a group represented by the formula:
• wherein p is 0 or 1, Z is a nitrogen atom or CH;
• R7, R8 and R9 are each a hydrogen atom, a halogen atom, an alkyl group having 1 to 5 carbon atoms, a nitro group, an amino group, an acetylamino group, an amino group substituted by 1 or 2 alkyl groups having 1 to 3 carbon atoms, a hydroxyl group, a cyano group, an alkyl group having 1 to 3 carbon atoms substituted by 1 to 3 halogen atoms, an alkoxy group having 1 to 5 carbon atoms or a phenyl group, or R7 and R8 are attached to the carbon atoms which are attached side by side, and together form a methylenedioxy group, or R7 and R8 are attached to the carbon atoms which are attached side by side, and together with the carbon atoms to which they attached form a benzene ring, R10 and R11 are each a hydrogen atom, or R10 and R11 together form an oxo group, a group represented by the formula:
• wherein R10 and R11 are as defined above, M is an oxygen atom, a sulfur atom, —NCH3 or —NH, or R12 and R13 are each a hydrogen atom, or R12 and R13 together with the carbon atoms to which they are attached form a benzene ring, (c) a pyridylacetyl group, (d) a cycloalkylmethyl group having 4 to 8 carbon atoms or (e) a 1,2-bis(ethoxy-carbonyl)vinyl group,
• R2 is the same group as defined for R1, a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkanoyl group having 2 to 6 carbon atoms or an alkoxycarbonyl group having 2 to 6 carbon atoms, R1 and R2 together form a group of the formula:
• ═CH—R14 wherein R14 is a phenyl group, a phenyl group substituted by nitro group(s), cyano group(s) or alkyl group(s) having 1 to 3 carbon atoms substituted by 1 to 3 halogen atoms, or an imidazolyl group, or R1 and R2 together with the nitrogen atom to which they are attached form a group represented by the formula:
• wherein W is CH, a carbon atom or a nitrogen atom, Y is a group of —C(═O) or —(CH2)m— wherein m is 1 or 2, R15 and R16 are each a hydrogen atom or when W is a 5 carbon atom, R15 and R16 together with the carbon atoms to which they are attached form a benzene ring or a naphthalene ring,
• R3 is a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a cinnamyl group,
• R4 is a hydrogen atom, an acetyl group, an ethylsuccinyl group or a nicotinoyl group,
• A is a group represented by the formula:
• —OC(═O)—R17,
• —OC(═O)—CH2—R17,
• —OC(═O)—NH—R17,
• —O—R17 or
• —OC(═O)—O—R17
• wherein R17 is a phenyl group, a pyridyl group, a quinolyl group, or those groups which are each substituted by 1 to 3 members selected from the group consisting of an alkyl group having 1 to 5 carbon atoms, a nitro group, an alkoxy group having 1 to 5 carbon atoms and a halogen atom, and
• R5 and R6 are each a hydrogen atom or an alkyl group having 1 to 5 carbon atoms or a pharmaceutically acceptable salt thereof.