RH blood group antigen compositions and methods of use
OwnerL. Scott Rodkey, Marwan A. Yared +1inventors
InventorsL. Scott Rodkey, Marwan A. Yared, Kenneth J. Moise, Jr.
Life of this patent
Estimating the term…
Abstract
Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
Claims25
A composition comprising an isolated and purified antigenically-active native Rh antigen protein or peptide.
An antigenically-active native Rh antigen protein or peptide prepared by a method comprising admixing said antigenically-active native Rh antigen protein or peptide with a low pH buffer.
Dependencies are inferred from the claim text.