Complex of human growth hormone and zinc
AssigneeTakeda Chemical Industries, Ltd.
InventorsYutaka Yamagata, Masafumi Misaki, Susumu Iwasa
Life of this patent
Estimating the term…
Abstract
The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.
Claims10
A sustained-release preparation, comprising a complex of human growth hormone and zinc containing the human growth hormone and the zinc at a molar ratio, of about 1:1.6 to about 1:2.4and a biodegradable polymer.
A method for producing a sustained-release preparation containing human growth hormone, which comprises dispersing a complex of human growth hormone and zinc human growth hormone to zinc at a molar ratio of about 1:1.6 to about 1:2.4 in an oil phase containing a biodegradable polymer to make a solid-in-oil emulsion, adding the solid-in-oil emulsion to water phase to make a solid-in-oil-in-water emulsion, and then subjecting the solid-in-oil-in-water emulsion to in-water drying.
Dependencies are inferred from the claim text.