Diethylenetriamine-N,N′,N″-triacetic acid derivatives

A chelator having the structure selected from the group consisting of:

• (a) a chelator, designated CHELATOR1, having the structure (A) of FIG. 1, which is
• wherein:
• m is 0 or 1;
• R1 has the structure shown in FIG. 1, which is
• wherein (a) is any combination of carbon, nitrogen, or sulfur atoms needed to complete a 5-, 6-, or 7- membered aromatic ring and R2 is selected from the group of ring substituents consisting of:
• —CO2H;
• —CH2CO2H;
• —SH;
• —CH2SH;
• and
• —C(═N—OR3)CO2H, wherein R3 is —CH3 or
• —C(CH3)2CO2tBu.
• (b) a chelator, designated CHELATOR2, having the structure (A) of FIG. 1 wherein m is 0 or 1, and R1 is selected from the group of ring systems consisting of structures (i) to (vi) of FIG. 5 which are the following, respectively:
• structure (i) is
• wherein R3 is selected from the group consisting of —CH3 and —C(CH3)2tBu;
• structure (ii) is
• structure (iii) is
• structure (iv) is
• structure (v) is
• and structure (vi) is
• (c) a chelator, designated CHELATOR3, having the structure (A) of FIG. 1 wherein m is 1 and R1 is selected from the group consisting of structures (i) and (ii) of FIG. 5
• (d) a chelator, designated CHELATOR4, having the structure shown below:
• R1—NH—C(O)—(CH2N(CH2CO2H)CH2—)m+2C(O)—R4
• wherein R1 has the structure shown in FIG. 1,
• wherein (a) in R1 of FIG. 1 is any combination of carbon, nitrogen, or sulfur atoms needed to complete a 5-, 6-, or 7-membered aromatic ring and R2 is selected from the group of ring substituents consisting of:
• —CO2H;
• —CH2CO2H;
• —SH;
• —CH2SH;
• and
• —C(═N—OR3)CO2H, wherein R3 is —CH3 or —C(CH3)2CO2tBu;
• m is 0 or 1;
• R4 is selected from the group consisting of:
• —NH—(CH2)n—NH2, wherein n is a number from 1 to 10;
• —NH—Ø—NH2;
• —NH—Ø—NCS;
• —NH—(CH2)n—NHC(S)NH—Ø—NCS, wherein n is a number from 1 to 10;
• and
• —NHR5, wherein R5 is selected from the group consisting of:
• -alkyl having from one carbon to ten carbons;
• -aryl having from six carbons to twenty carbons;
• -sulfonated alkyl having from one carbon to ten carbons;
• and -sulfonated aryl having from six carbons to twenty carbons;
• and
• (e) a chelator, designated CHELATOR5, having the structure, represented by formula (E), below:
• R1—NH—C(O)—(CH2N(CH2CO2H)CH2—)m+2COOH (E)
• wherein m is 0 or 1;
• and
• R1 has the structure shown in FIG. 1, wherein (a) is any combination of carbon, nitrogen, or sulfur atoms needed to complete a 5-, 6-, or 7-membered aromatic ring and R2 is selected from the group of ring substituents consisting of:
• —CO2H;
• —CH2CO2H;
• —SH;
• —CH2SH;
• and
• —C(═N—OR3)CO2H, wherein R3 is —CH3 or —C(CH3)2CO2tBu.