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US 6,190,921 B1Granted
Ouabain immunoassay and kit and ouabain labeled with 125I or fluorescent label
OwnerPekka Juhani Leppäluoto, Lauri Erkki Olli Vakkuri +1inventors
InventorsPekka Juhani Leppäluoto, Lauri Erkki Olli Vakkuri, Olli Jaakko Vuolteenaho
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Abstract
The invention deals with the use of a reactive compound in immunological analyses. The compound is ouabain or its analog to which another compound, labeled by radioiodine or by a fluorogen, is coupled. The invention covers also the method to measure ouabain or its analog in plasma to diagnose cardiovascular and endocrine diseases and other harmful conditions.
Claims4
An immunologically reactive complex comprising three members, ouabain, a compound and an element, to be used as a tracer in ouabain immunoassays in which
- a) said compound coupled to ouabain is tyrosine or histidine or a peptide or protein containing tyrosine or histidine,
- b) said element attached to said compound is radioactive iodine, 125I, or lanthadine selected from the group consisting of Europium, Terbium or Samarium, or a group labeled by radioactive iodine, preferably 125I, or by lanthadine selected from the group consisting of Europium, Terbium or Samarium.
Dependencies are inferred from the claim text.