KUZ, a novel family of metalloproteases
AssigneesThe Regents of the University of California, Yale University
InventorsGerald M. Rubin, Duojia Pan, Jenny Rooke, Reza Yavari, Tian Xu
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Abstract
Members of a novel family of polypeptides, the KUZ family, are metalloproteases involved in neuronal partitioning and neuronal development. The invention provides KUZ poylpeptides, antibodies that bind the KUZ polypeptides, KUZ encoding nucleic acids, methods for identifying cells expressing the KUZ polypeptides, methods of identifying ligands that bind to the subject proteins and methods of blocking KUZ polypeptide/ligand interactions.
Claims13
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of residues 320-673 of SEQ ID NO:2, residues 212-454 of SEQ ID NO:4, SEQ ID NO:6, and residues 213-455 of SEQ ID NO:8.
A dominant-negative mutant of a KUZ polypeptide, said mutant comprising (a) an amino acid sequence selected from the group consisting of SEQ ID NO:2, 4 and 6, wherein the protease domain is deleted, or (b) SEQ ID NO:2, wherein glutamate at residue 606 is substituted with alanine.
Dependencies are inferred from the claim text.