Methods for identifying compounds that bind to CSAPK-1

A method for identifying a compound which modulates the activity of a naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, wherein the allelic variant is encoded by a nucleic acid module which hybridizes to the complement of a nucleic acid molecule consisting of SEQ ID NO:1 or 3, in 6×SSC at 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C., and wherein the naturally occurring allelic variant of the polypeptide is at least 302 amino acids in length,

• the method comprising:
• a) contacting a cell expressing the allelic variant with a test compound under conditions suitable for modulation of the activity of the allelic variant;
• and
• b) detecting modulation of the activity of the allelic variant by the test compound.

A method for identifying a compound which modulates the activity of a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 98% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 or 3, wherein the polypeptide is at least 302 amino acids in length,

• the method comprising:
• a) contacting a cell expressing the polypeptide with a test compound under conditions suitable for modulation of the kinase activity of the polypeptide;
• and
• b) detecting modulation of the kinase activity of the polypeptide by the test compound.

A method for identifying a compound which modulates the activity of a naturally occurring allelic variant of a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, wherein the allelic variant is encoded by a nucleic acid molecule which hybridizes to the complement of a nucleic acid molecule consisting of SEQ ID NO:1 or 3, in 6×SSC at 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C., and wherein the naturally occurring allelic variant of the polypeptide is at least 302 amino acids in length,

• the method comprising:
• a) contacting the allelic variant with a test compound under conditions suitable for modulation of the activity of the polypeptide;
• and
• b) detecting modulation of the activity of the allelic variant by the test compound.

A method for identifying a compound which modulates the activity of a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 98% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:1 or 3, wherein the polypeptide is at least 302 amino acids in length,

• the method comprising:
• a) contacting the polypeptide with a test compound under conditions suitable for modulation of the kinase activity of the polypeptide;
• and
• b) detecting modulation of the kinase activity of the polypeptide by the test compound.