Regulation of wound healing by nitric oxide
AssigneeNew York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery
InventorGeorge Anthony Calvert Murrell
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Abstract
The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissues. Also provided are methods and compositions for inhibiting unwanted wound healing by inhibiting the activity of nitric oxide in the tissue.
Claims7
A method for promoting the healing of damaged tissue in a patient in need of such treatment, comprising exposing said tissue to an effective amount of an agent that increases local concentration of nitric oxide compared to the concentration of nitric oxide in said tissue in the absence of said agent, wherein said tissue is a member selected from the group consisting of muscle, tendon, ligament, and bone, said damage comprises surgical incisions, traumna, and endogenous pathological processes and said healing comprises the recruitment of inflammatory cells, followed by fibroblasts, to the site of the tissue damage.
Dependencies are inferred from the claim text.