Methods for treating inflammatory conditions
AssigneeAdolor Corporation
InventorVivien H. W. Mak
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Abstract
The present invention provides a number of screening methods for evaluating compounds capable of suppressing cytokine production either in vitro or in vivo. The methods generally involve stimulating the production of a cytokine in a cell, exposing a portion of the cells to a putative cytokine modulating agent and determining subsequent levels of cytokine production in the cells. Additionally, the present invention provides certain compounds identified by this method.
Claims35
A method of inhibiting production of tumor necrosis factor (TNF) in a mammal, comprising:
- administering to said mammal a composition comprising a TNF production-inhibitory amount of a compound selected from loperamide and diphenoxylate to the animal.
A method of treating an inflammatory skin condition, comprising topically applying loperamide.
A method of treating a skin inflammatory condition mediated by tumor necrosis factor (TNF) production in a mammal, comprising:
- administering to the mammal a composition comprising loperamide in an amount effective to relieve or prevent the condition in the mammal.
Dependencies are inferred from the claim text.