Sustained/immediate acting ketoprofen patch and process for manufacturing the same

A method for manufacturing a ketoprofen patch comprising the steps of:

• a first step of forming a primer by coating an adhesive selected from the group consisting of a rubber adhesive and an acrylic adhesive containing solid matter onto a silicon coated paper, or polyester film, drying and transfer coating onto a backing;
• a second step of forming a drug layer by coating a drug solution onto a silicon coated paper, drying and transfer coating onto said primer, said drug solution being prepared by mixing aqueous polyvinyl alcohol and an acrylic adhesive with at least one compound selected from the group consisting of an ethylene-vinyl acetate copolymer and a synthetic rubber latex to obtain a mixture, and adding to said mixture a solution obtained by dissolving a therapeutically effective amount of ketoprofen powder in at least one enhancer;
• and
• a third step of forming a skin adhesion layer, having a thickness in the range of between substantially 5 to 40 μm, by dissolving emulsifier in ethyl-acetate to obtain a solution, mixing said solution with acrylic adhesive, stirring thus obtained mixture, coating said mixture onto a silicon coated paper, drying and transfer coating onto said drug layer.