Injectable bio-active glass in a dextran suspension
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsLarry L. Hench, Jon K. West, Guy LaTorre, June Wilson, William Toreki, III, Christopher Batich
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Abstract
The present invention relates to injectable suspensions of bio-active glass and dextran or a dextran derivative for the repair of soft tissue or hard bone in mammals, especially humans. In one embodiment, the dextran derivatives include free radical polymerizable groups, which can be polymerized following injection into a patient.
Claims15
A pharmaceutically acceptable fluid composition particularly adapted for injection via a surgical needle into an animal, comprising a suspension or dispersion of bio-active and bio-compatible glass particles and dextrans or dextran derivatives having an average molecular weight of about 10,000 to about 2×106.
A method for repair, replacement, reconfiguration, reconstruction or augmentation of selected soft tissue and/or hard tissue (bone) anatomic structures in a patient in need thereof comprising injecting into the soft tissue and/or hard tissue (bone) of the patient a homogeneous suspension of bio-active and bio-compatible glass particulate composition having a particle size from about 250 micrometers to about 90 micrometers in an aqueous solution of dextrans or of dextran derivatives having an average molecular weight of about 10,000 to about 2,000,000 Daltons and optionally one or more preservative, coloring, flow enhancing, or suspension enhancing agents.
Dependencies are inferred from the claim text.