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US 6,190,667 B1Granted
Methods of inhibiting Helicobacter pylori
AssigneeInstitut Pasteur
InventorsHilde De Reuse, Stéphane Skouloubris, Valérie Cussac, Agnès Labigne
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Abstract
This invention relates to methods of screening molecules capable of inhibiting the survival of Helicobacter pylori in vivo by specifically inhibiting the activity of UreI, to the molecules identified by these methods, and to the use of these molecules to treat or prevent H. pylori infection.
Claims11
A method for screening a molecule capable of inhibiting the growth or survival of Helicobacter, comprising:
- (a) contacting a parental Helicobacter strain with said molecule in a biological sample and contacting a Helicobacter strain deficient in UreI with said molecule;
- (b) comparing the acidity sensitivity of the parental strain to the acidity sensitivity of the UreI deficient strain, both of which have been contacted with the molecule of step (a);
- and
- (c) selecting said molecule that increases the acidity sensitivity of the parental strain as compared to the effect of said molecule on the acidity sensitivity of the UreI deficient strain, wherein acidity sensitivity is correlated with inhibiting Helicobacter growth or survival.
1 more element
Dependencies are inferred from the claim text.