Back to results
US 6,190,659 B1Granted
Bacterial plasmin binding protein and methods of use thereof
AssigneeThe Rockefeller University
InventorsVijaykumar Pancholi, Vincent A. Fischetti
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeThe Rockefeller University
InventorsVijaykumar Pancholi, Vincent A. Fischetti
Estimating the term…
The present invention describes a novel polypeptide, and methods of its use in effective thrombolytic therapy in the treatment of coronary and pulmonary thrombosis. Its use is also disclosed in vaccines to abrogate a streptococcal infection. Pharmaceutical compositions containing the novel polypeptide are included. One particular form of the novel polypeptide is streptococcal surface enolase (SEN), a specific binding protein for human plasmin and/or human plasminogen on group A streptococci that displays classical α-enolase activity, i.e., it can catalyze the dehydration of D-glycerate-2-phosphate to phosphoenolpyruvate. In addition, SEN impedes the inhibition of the fibrinolytic activity of plasmin by α2-antiplasmin and can bind plasminogen without preventing streptokinase from cleaving this plasmin precursor.
An isolated polypeptide having the following characteristics:
An immunogenic fragment of an isolated polypeptide, wherein said polypeptide has the following characteristics:
A chimeric protein comprising an isolated polypeptide having the following characteristics:
Dependencies are inferred from the claim text.