Method for treating neoplasia using humanized antibodies which bind to antigen A33
AssigneesLudwig Institute for Cancer Research, Sloan-Kettering Institute for Cancer Research
InventorsSydney Welt, Gerd Ritter, Leonard Cohen, Clarence Williams, Jr., Elizabeth Carswell Richards, Mary John, Lloyd J. Old
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Abstract
The invention involves the therapeutic use of humanized antibodies, fragments, etc., which bind to the antigen A33. These antibody molecules are useful in the treatment of various neoplasias, including colon cancer. Various modes of administration, and doses are described.
Claims6
A method for causing regression of a colorectal carcinoma or a gastric carcinoma in a subject in need thereof, comprising administering to said subject an amount of a 111In radiolabelled humanized monoclonal antibody or a 111In radiolabelled binding fragment of a humanized monoclonal antibody, said 111In radiolabelled humanized monoclonal antibody or 111In radiolabelled antigen binding fragment of said humanized monoclonal antibody binding to antigen A33 which is presented on surfaces of cells of said colorectal carcinoma or gastric carcinoma, and wherein said amount is effective for provoking regression of said colorectal carcinoma or said gastric carcinoma.
Dependencies are inferred from the claim text.