Methods and apparatus for inactivating contaminants in biological fluid
AssigneeBaxter International Inc.
InventorsJohn R. Chapman, Peter R. H. Stark, Michael V. Swallow, Dale N. Larson
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Abstract
Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants.
Claims29
Apparatus for treating a biological fluid with light comprising:
- a light chamber defined by at least two pair of facing, reflective walls wherein each of said pair of walls substantially defines a compound parabolic curve;
- a high intensity light source disposed within said chamber;
- and
- a fluid treatment region exterior to said light chamber, said fluid treatment region adapted to hold a quantity of biological fluid.
A method for substantially inactivating contaminants in a biological fluid comprising:
- providing a quantity of a biological fluid;
- combining said biological fluid with a selected amount of a phenothiazine dye whereby the concentration of said phenothiazine dye is between approximately 2-4 μM;
- and
- contacting said combination of biological fluid and phenothiazine dye with a high intensity light of greater than about 30 mW/cm2.
Apparatus for inactivating contaminants in a biological fluid comprising:
- a first high intensity light source for providing light having an intensity of between approximately 80-150 mW/cm2 in the wavelength range of between approximately 550-700 nm;
- a second high intensity light source for providing light having an intensity of between approximately 80-150 mW/cm2 in the wavelength range of between approximately 550-700 nm;
- and
- a fluid treatment region located between said first and second light sources, wherein each of said light sources is separated from said fluid treatment region by a window which substantially transmits light in said wavelength range but does not substantially transmit selected unwanted light.
Dependencies are inferred from the claim text.