Loading patent…
AssigneeCroix-Rouge de Beligique Departement Central de Fractionnement
InventorsRuth Laub, Luc De Wael, Mario Di Giambattista
Estimating the term…
A method and apparatus for inactivating contaminants, particularly nonenveloped viruses, in blood products without the need for quenchers in the blood products. The blood product is flowed through a flow meter at a controlled flow rate and subjected to type C ultraviolet radiation, where the irradiation dose received by the blood product is less than 640 joules/m2. The blood product does not contain quenchers when being irradiated, and the blood product retains more than 85% of its Factor VIII activity after being subjected to the radiation. The produced blood product is free of viruses and quenchers, avoiding potential toxicity due to the quenchers. The apparatus includes a source of UVC light, a quartz tube containing the blood product while it is exposed to the UVC light, a flow meter for controlling the flow rate of the blood product to be treated, and a pump. The UV light preferably emits light at 254 nm.
A method of inactivating nonenveloped viruses present in a blood product, comprising flowing the blood product past one or more emission(s) of type C ultraviolet radiation while controlling the flow of the blood product such that the irradiation doses of ultraviolet radiation which are received by the blood product are lower than 640 joules/m2 and the blood product retains more than 85% of its activity and is substantially free of nonenveloped viruses, wherein the blood product does not contain quenchers when said blood product is subjected to said one or more emissions of type C ultraviolet radiation.
An apparatus for viral inactivation of a blood product, comprising:
Dependencies are inferred from the claim text.