Guanidine derivatives and process for their production
AssigneeKao Corporation
InventorsMinoru Nagai, Hiromitsu Kawada, Mayumi Tsuchiya, Seiji Yamasaki, Akira Yamamuro, Toshiya Ono
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Abstract
A guanidine derivative represented by formula (1), (2), (3) or its acid addition salt and a production process thereof wherein each of A and B is a C2-C8 alkylene, D is a single bond, —CO— or a C1-C6 alkylene, E is H, a lower alkyl or the like, m is 1 to 6, n is 0 to 6 and R1 is H, a lower alkyl or the like, 1 is 1 to 10 and G is H, —OH or the like and a skin cosmetic containing the same. It can exert excellent keratin layer softening effect continuously for a long period of time.
Claims6
A guanidine derivative represented by the following formula (1) or an acid addition salt thereof
- wherein A and B may be the same or different from each other and each represents an alkylene group having 2 to 8 carbon atoms, D represents a single bond, —CO— or an alkylene group having 1 to 6 carbon atoms, E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an aryl group which may have a substituent group, m is an integer of 1 to 6, n is an integer of 0 to 6 and R1 represents a hydrogen atom, a lower alkyl group or —(AO)m—(BO)n—D—E, with the provisos that
- a. R1 is not hydrogen atom nor a methyl group when A is a straight chain alkylene group, m=1 and n=0, that
- b. —(AO)m—(BO)n—D—E is not a hydroxyethyl group when R1 is a hydrogen atom, a lower alkyl group or a hydroxyethyl group, and that
- c. —(AO)m—(BO)n—D—E is not a lower alkoxyethyl group when R1 is hydrogen atom.
A process for producing a guanidine derivative represented by the following formula (1) or an acid addition salt thereof
- wherein A and B may be the same or different from each other and each represents an alkylene group having 2 to 8 carbon atoms, D represents a single bond, —CO— or an alkylene group having 1 to 6 carbon atoms, E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an aryl group which may have a substituent group, m is an integer of 1 to 6, n is an integer of 0 to 6 and R1 represents a hydrogen atom, a lower alkyl group or —(AO)m—(BO)n—D—E, with the provisos that
- a. R1 is not hydrogen atom nor a methyl group when A is a straight chain alkylene group, m=1 and n=0, that
- b. —(AO)m—(BO)n—D—E is not a hydroxyethyl group when R1 is a hydrogen atom, a lower alkyl group or hydroxylethyl group and that
- c. —(AO)m—(BO)n—D—E is not a lower alkoxyethyl group when R1 is hydrogen atom, which comprises allowing a guanidylation reagent to react with an amine represented by the following formula (4)
- wherein A, B, D, E, m, n and R1 are as defined above.
Dependencies are inferred from the claim text.