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US 6,187,932 B1Granted
Simple process for producing high quality captopril
AssigneeKaneka Corporation
InventorsKoichi Kinoshita, Fumihiko Kano, Takahiro Okubo, Yasuyoshi Ueda
Life of this patent
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Abstract
A process for producing captopril of the following formula (1) comprising subjecting a substrate compound of the following general formula (2) to a hydrolysis reaction in aqueous medium to remove the RCO group and isolating the product compound, said hydrolysis reaction in aqueous medium being conducted in the presence of a strong acid at pH not over 1 and a reaction temperature not below 40° C.
Claims25
A process for producing captopril of the following formula (1)
- comprising subjecting a substrate compound of the following formula (2)
- wherein R represents alkyl or alkoxy, to hydrolysis reaction in aqueous medium to remove RCO group and isolating, said hydrolysis reaction in aqueous medium being conducted in the presence of a strong acid at pH not over 1 and a reaction temperature not below 40° C.
Dependencies are inferred from the claim text.