Back to results
US 6,187,926 B1Granted
Process for producing quinolone derivatives
AssigneeKirin Beer Kabushiki Kaisha
InventorsTatsushi Osawa, Kazuo Kubo, Hideko Murooka, Tatsuo Nakajima
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for producing a 4-quinolone derivative, comprising allowing an o-aminoacetophenone derivative to react with a formic acid in an aprotic solvent in the presence of a suitable base, and adding a protic solvent to the reaction mixture. This is a simple process for producing 4-quinolone derivatives, applicable to large-scale commercial production.
Claims21
A process for producing a quinolone derivative represented by the formula (I):
- wherein
- A, B, C and D are independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxyl, lower alkylcarbonyl, lower alkoxycarbonyl, lower alkylthio, lower alkylamino, di-lower alkylamino, halogen, trifluoromethyl and nitro, comprising:
- reacting a compound represented by the formula (II):
- wherein A, B, C and D are as defined above,
- with a formic acid ester in an aprotic solvent selected from the group consisting of aromatic hydrocarbons, ether solvents, acetonitrile and dimethylformamide, in the presence of a base, and
- adding a protic solvent to the reaction mixture.
3 more elements
Dependencies are inferred from the claim text.