Bridged aromatic substituted amine ligands with donor atoms

A compound of the formula:

• wherein:
• n=0 or 1;
• R1 and R2 are independently selected from hydrogen, ═O, with the proviso that both are not ═O, —(CH2)m—Z where m is 0-10 and Z represents a conjugation group or targeting moiety, and —(CH2)m—W where m is 0-10 and W represents a hydrolyzable group, or R1 and R2 are taken together to form a cyclic anhydride or a benzene ring;
• R3 is hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z or —(CH2)m—W;
• R4 and R5 are attached at one or more of the ring positions and are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z and —(CH2)m—W;
• R6 and R7 are independently selected from hydrogen with the proviso that both are not hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z, —(CH2)m—W— and
• where Q represents a multivalent acid functionality group able to coordinate with metal ions, and p=0 to 1;
• R12 and R13 are independently selected from hydrogen, hydroxyl, carboxyl, phosphoric, and hydrocarbon radicals having from 1-10 carbon atoms, and physiologically acceptable salts of the acid radicals;
• X, X′, Y and Y′ are independently selected from carbon and sulfur to independently form 5 or 6 member aromatic rings wherein the remaining ring atoms are carbon;
• A and A′ are nitrogen, where A bears R8 and R10 and A′ bears R9 and R11, wherein R8 and R10 are joined to form a cyclic anhydride or R9 and R11 are joined to form a cyclic anhydride or both, and any of R8, R9, R10 and R11 not joined to form a cyclic anhydride are independently selected from hydrogen, lower alkyl, alkoxy, halogen, hydroxyl, nitro, —(CH2)m—Z, —(CH2)m—W and
• the compound has at least one Z, W or Q.