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US 6,187,907 B1Granted
Triple helix coil template having a biologically active ligand
OwnerJames Chen, Li-An Yehinventors
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Abstract
A template-ligand conjugate including (1) a template made of three cross-linked polypeptide chains, wherein the three polypeptide chains each contain tripeptide or hexapeptide repeat sequences aligned to form a triple helix coil; and (2) at least one biologically active ligand attached to the template via covalent bonding with one of the three polypeptide chains.
Claims27
A template-ligand conjugate comprising:
- a template made of three cross-linked polypeptide chains, wherein the three polypeptide chains each contain tripeptide or hexapeptide repeat sequences aligned to form a triple helix coil;
- and
- a first biologically active ligand attached to the template via covalent bonding with one of the three polypeptide chains, wherein the first biologically active ligand does not contribute to the triple helix coil formed by the template.
Dependencies are inferred from the claim text.