Protein kinase C activators and their use in decreasing expression of cell antigens
AssigneeThe Trustees of Columbia University in the City of New York
InventorsPaul B. Fisher, Jorge A. Leon
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Abstract
A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.
Claims10
A method of detecting tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of cell antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen.
Dependencies are inferred from the claim text.