Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds
AssigneeSouthern Illinois University School of Medicine
InventorKathleen C. M. Campbell
Life of this patent
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Abstract
Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent. Combinations of these time periods can also be employed.
Claims36
A method for preventing or reducing ototoxicity in a patient selected from the group consisting of a human, a cat, and a dog undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound, comprising administering to said patient an anti-ototoxic effective amount of D-methionine, wherein the D-methionine is substantially free of the L-isomer.
A method for preventing or reducing ototoxicity in a patient undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound selected from the group consisting of cisplatin, carboplatin, and iproplatin, comprising:
- intravenously administering to said patient about 10 mg/kg body weight to about 75 mg/kg body weight of D-methionine, or a pharmaceutically acceptable salt thereof, or
- D-methionine or a pharmaceutically acceptable salt thereof in a molar ratio of about 18.75:1, D-methionine:anti-tumor platinum-coordination compound,
- within about one-half hour before administration of said anti-tumor platinum-coordination compound to about one-half hour after administration of said anti-tumor platinum-coordination compound, wherein the D-methionine is substantially free of the L-isomer.
A method for preventing or reducing weight loss in a patient selected from the group consisting of a human, a cat, and a dog undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound, comprising administering to said patient an anti-weight loss effective amount of D-methionine, wherein the D-methionine is substantially free of the L-isomer.
A method for preventing or reducing gastrointestinal toxicity in a patient selected from the group consisting of a human, a cat, and a dog undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound, comprising administering to said patient an anti-gastrointestinal toxicity effective amount of D-methionine, wherein the D-methionine is substantially free of the L-isomer.
A method for preventing or reducing neurotoxicity in a patient selected from the group consisting of a human, a cat, and a dog undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound, comprising administering to said patient an anti-neurotoxicity effective amount of D-methionine, wherein the D-methionine is substantially free of the L-isomer.
A method for preventing or reducing alopecia in a patient selected from the group consisting of a human, a cat, and a dog undergoing treatment with a chemotherapeutic effective amount of an anti-tumor platinum-coordination compound, comprising administering to said patient an anti-alopecia effective amount of D-methionine, wherein the D-methionine is substantially free of the L-isomer.
Dependencies are inferred from the claim text.