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US 6,187,810 B1Granted
Macrocyclic compounds made from suboxide units
AssigneeDonatur Dr. Kerek GmbH
InventorFranz Kerek
Life of this patent
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Abstract
The invention relates to macrocyclic substances which are bioregulatory active and a method for their synthetic production as well as its isolation from various starting materials. The application of these active substances as such or in combination with other active substances for enzyme regulation and bioregulation is also described.
Claims24
A macrocyclic compound consisting of n carbon suboxide (C3O2) units which form n linearly condensed 4-pyrone or 2-pyrone rings which are joined in a macrocycle, wherein n is 4, 6, 8 or 10.
A pharmaceutical composition comprising:
- (A) a member selected from the group consisting of:
- a macrocyclic compound consisting of n carbon suboxide (C3O2) units which form n linearly condensed 4-pyrone or 2-pyrone rings which are joined in a macrocycle, wherein n is 4, 6, 8 or 10,
- an oligomer of a macrocyclic compound consisting of n carbon suboxide (C3O2) units which form n linearly condensed 4-pyrone or 2-pyrone rings which are joined in a macrocycle, wherein n is 4, 6, 8 or 10, wherein said oligomer has an oligomerization degree s of 2, 3, 4, 5, 6, 10 or 12,
- an adduct formed between a macrocyclic compound consisting of n carbon suboxide (C3O2) units which form n linearly condensed 4-pyrone or 2-pyrone rings which are joined in a macrocycle, wherein n is 4, 6, 8 or 10, and an inorganic compound selected from the group consisting of hydrogen, water, ammonia and an alkali salt, and
- an adduct formed between an oligomer of a macrocyclic compound consisting of n carbon suboxide (C3O2) units which form n linearly condensed 4-pyrone or 2-pyrone rings which are joined in a macrocycle, wherein n is 4, 6, 8 or 10, wherein said oligomer has an oligomerization degree s of 2, 3, 4, 5, 6, 10 or 12, and an inorganic compound selected from the group consisting of hydrogen, water, ammonia and an alkali salt;
- and
- (B) a pharmaceutically acceptable carrier.
4 more elements
Dependencies are inferred from the claim text.