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AssigneeMerrell Pharmaceuticals Inc.
InventorsJames K. Woodward, Richard A. Okerholm, Mark G. Eller, Bruce E. McNutt
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The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective antihistaminic amount of a compound of the formula wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A and B is hydrogen or hydroxy with the proviso that at least one of A or B is hydrogen; or a pharmaceutically acceptable salt and individual isomers thereof.
A method of treating a histaminic-mediated condition in a patient in need thereof but susceptible to possible cardiac events associated with the administration of terfenadine, said method comprising administering to said patient an effective antihistaminic amount of a compound of the formula:
A method of treating a histamine-mediated disease in a human while avoiding the concomitant liability of cardiac arrhythmias associated with the administration of terfenadine, comprising administering to said human a therapeutically effective amount of racemic terfenadine carboxylate or a pharmaceutically acceptable salt thereof.
In a method of providing an antihistaminic effect in a patient susceptible to QT prolongation and/or ventricular tachycardia when using terfenadine, the improvement which comprises administering to said patient an effective amount of a compound of the formula:
Dependencies are inferred from the claim text.