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US 6,187,787 B1Granted
Bis(9-aminoacridine) DNA intercalating agents having antitumor activity
AssigneeTrustees of Dartmouth College
InventorsGordon W. Gribble, Gary D. Jaycox, Michael Mosher
Life of this patent
Estimating the term…
Abstract
A series of bis-acridinyl DNA intercalating agents with anticancer cell activity represented by formula (I), where Z is a linear arrangement of multiple aromatic rings, containing at least three aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner are provided. Methods of inhibiting cancer cells and treating patients having cancer with these agents are also provided.
Claims4
A compound having formula (I):
- wherein Z is selected from a group consisting of
- in either a cis-cis, cis-trans, or trans-trans configuration,
Dependencies are inferred from the claim text.