Phenanthridinium derivatives
AssigneeNippon Kayaku Kabushiki Kaisha
InventorsAkira Masuda, Masato Suwa, Masanobu Suzuki
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Abstract
A novel phenanthridinium derivative represented by general formula (A): wherein R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group; R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally be substituted with a substituent selected from the group consisting of a lower alkyl group, a halogen and a hydroxy group; each of Y and Z independently represents a hydrogen, a hydroxy or a lower alkoxy group; or Y and Z are combined together to form methylenedioxy or a phenyl ring; and, X− is an acid residue or a hydrogen acid residue, exhibits an antitumor activity and has resistance to chemical reduction as well as biological metabolic reactions and is thus advantageous for use as a medicine.
Claims7
A novel phenanthridinium derivative compound represented by general formula (A):
- wherein
- R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group;
- R is an aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally be substituted with a substituent selected from the group consisting of a lower alkyl group, a halogen and a hydroxy group;
- each of Y and Z independently represents a hydrogen, a hydroxy or a lower alkoxy group;
- or Y and Z are combined together to form methylenedioxy or a phenyl ring;
- and,
- X− is an acid residue or a hydroacid residue.
A novel phenanthridinium derivative compound represented by general formula (B):
- wherein
- R1 is a substituted or unsubstituted lower aliphatic hydrocarbon group;
- R is a lower aliphatic hydrocarbon chain having 2 to 6 carbon atoms which may optionally be substituted with a substituent selected from the group consisting of a lower alkyl group, a halogen and a hydroxy group;
- each of Y and Z independently represents a hydrogen, a hydroxy or a lower alkoxy group;
- or Y and Z are combined together to form methylenedioxy or a phenyl ring.
A 2,3-(methylenedioxy)-7-hydroxy-8-methoxy-5,6-propano-benzo[c]phenanthridinium salt.
Dependencies are inferred from the claim text.