Acridone-derived compounds useful as antineoplastic and antiretroviral agents
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsChristopher J. Michejda, Marek W. Cholody, William G. Rice, James A. Turpin
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Abstract
The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compounds are anti-neoplastic agents useful in the treatment of various forms of cancer. wherein R1 and R2 are independently —H, —OH, amino, alkylamino, dialkylamino, alkoxy, alkyl, haloalkyl or halogen; n is 2 to 6, X and X′ are independently —N or —NO2; Y and Y′ are independently —N or —CH, or —H; and the double-slash represents a double bond or no bond.
Claims5
A compound having the formula (I):
- wherein
- R1 and R2 are independently —H, —OH, amino, C1-C8 alkylamino, C1-C8 dialkylamino, C1-C8 alkoxy, C1-C8 alkyl, C1-C8 haloalkyl or halogen;
- n is 2 to 6;
- X and X′ are independently —N or —NO2;
- Y and Y′ are independently —N or —CH, or —H;
- and double-slash represents a double bond or no bond;
- such that when X or X′ is —N, Y or Y′ is —CH or —N, and the double-slash is a double bond, and when X or X′ is —NO2, Y or Y′ is —H, and the double slash is no bond.
A method of inhibiting neoplastic cell growth comprising:
- administering an effective amount of a compound having the formula:
- wherein
- R1 and R2 are independently —H, —OH, amino, C1-C8 alkylamino, C1-C8 dialkylamino, C1-C8 alkoxy, C1-C8 haloalkyl or halogen;
- n is 2 to 6;
- X and X′ are independently —N or —NO2;
- Y and Y′ are independently —N or —CH, or —H;
- and double-slash represents a double bond or no bond;
- such that when X or X′ is —N, Y or Y′ is —CH or —N, and the double-slash is a double bond, and when X or X′ is —NO2, Y or Y′ is —H, and the double slash is no bond.
Dependencies are inferred from the claim text.