Benzoxazepine derivatives and their salts and medicaments containing the same

A benzoxazepine derivative and its salts having the formula (III):

• wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxyalkyl group, C1 to C4 halogenoalkyl group, cyano group, or COOEt group, R2 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxy group, or hydroxy group, a dotted line represents an optional double bond, and Z′ indicates a monocyclic or polycyclic heterocyclic group selected from the group consisting of pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, quinolyl group, isoquinolyl group, quinoxalinyl group, quinazolinyl group, 2-thiazolyl group, 2-oxazolyl group, 2-benzthiazolyl group, 2-benzoxazolyl group, 3-isothiazolyl group, 2-thienyl group, and 3-thienyl group, which may be unsubstituted or substituted with a C1-C4 lower alkyl group, a C1-C4 lower alkoxy group, hydroxy group, amino group, and/or halogen atom.

A benzoxazepine derivative of the following formula (V) and its salts:

• wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1-C4 lower alkyl group, C1-C4 lower alkoxyalkyl group, C1-C4 halogenalkyl group, cyano group or COOEt group, R2 indicates a hydrogen atom, halogen atom, C1-C4 lower alkyl group, C1-C4 lower alkoxy group, or hydroxy group, and Q indicates a leaving group which is replaced with a hydroxy group, alkoxy group, halogen or amino group.

A benzoxazepine derivative of the following formula (VI) and its salts:

• wherein n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1-C4 lower alkyl group, C1-C4 lower alkoxyalkyl group, C1-C4 halogenalkyl group, cyano group or COOEt group, R2 indicates a hydrogen atom, halogen atom, C1-C4 lower alkyl group, C1-C4 lower alkoxy group, or hydroxy group, Z′ is a monocyclic or polycyclic heterocyclic group, selected from the group consisting of pyridyl group, pyrimidinyl group, pyrazinyl group, pyridazinyl group, quinolyl group, isoquinolyl group, quinoxalinyl group, quinazolinyl group, 2-thiazolyl group, 2-oxazolyl group, 2-benzthiazolyl group, 2-benzoxazolyl group, 3-isothiazolyl group, 2-thienyl group, and 3-thienyl group, which may be unsubstituted or substituted with a C1-C4 lower alkyl group, a C1-C1 lower alkoxy group, hydroxy group, amino group, and/or halogen atom, and X indicates a halogen atom.