Canine parvovirus DNA vaccination
AssigneeAkzo Nobel N.V.
InventorsIan Tarpey, Neil Greenwood
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Abstract
This invention relates to the use of a DNA vaccine for the manufacture of a medicament for use in eliciting an immune response against parvovirus in a maternally derived antibody positive animals. The DNA vaccine comprises a plasmid vector and at least one isolated nucleotide sequence encoding a parvovirus immunogenic polypeptide, and transcriptional regulatory sequences operably linked to the isolated nucleotide sequence.
Claims17
A method for protecting a maternally-derived antibody positive animal against a parvovirus comprising, administering to said animal a parvovirus DNA vaccine, said DNA vaccine comprising a vector, said vector comprising in operable linkage;
- at least one isolated nucleotide sequence encoding a parvoviral VP1 polypeptide or a parvoviral VP2 polypeptide, and
- one or more transcriptional regulatory sequences,
- wherein said DNA vaccine elicits an immune response in said animal that is protective against parvovirus.
A plasmid vector comprising a DNA sequence encoding the VP2 polypeptide of canine parvovirus type 2a, which is deposited at the European Collection of Animal Cell Culture, Porton Down, UK under accession no. 97012801.
A canine parvovirus DNA vaccine comprising the plasmid vector deposited with the European Collection of Animal Cell Culture, Porton Down, UK under accession no. 97012801 in a physiologically acceptable medium.
A DNA molecule comprising a vector, at least one isolated nucleotide sequence encoding a parvovirus immunogenic polypeptide, and one or more transcriptional regulatory sequences operably linked to the isolated nucleotide sequence, which will elicit an immune response against parvovirus in a maternally-derived antibody positive animal, wherein said vector is a plasmid vector which is deposited at the European Collection of Animal Cell Culture, Porton Down, UK under accession no. 97012801.
Dependencies are inferred from the claim text.