Pharmaceutical compositions based on dalfopristine and on quinupristine, and preparation thereof
AssigneeRhone-Poulenc Rorer S.A.
InventorsGuillaume Conrath, Joël Vacus, Nicholas Paul Barker
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Abstract
The present invention relates to injectable compositions containing a dalfopristine/quinupristine combination comprising an aqueous solution containing the dalfopristine/quinopristine combination and an additive intended to avoid or reduce the intolerance effects at the site of injection.
Claims46
An injectable composition, said composition comprising an aqueous solution of dalfopristine and quinupristine, and an additive effective to avoid or reduce intolerance effects at the site of injection.
A twin-compartment for preparing a solution for injection, said twin-compartment comprising a first compartment containing an aqueous solution of dalfopristine and quinupristine, and a second compartment containing an additive effective to avoid or reduce intolerance effects at the site of injection.
A method for protecting against venous intolerance effects caused by the injection of a composition containing quinupristine and dalfopristine, said method comprising adding to said composition prior to injection a buffer solution selected from any pharmaceutically acceptable aqueous solution that is buffered to an acid pH, that is capable of fixing the pH of the composition at a value below the pH of blood plasma, and that is capable of fixing the pH of the composition at a value that does not cause immediate or rapid degradation of the quinupristine, dalfopristine, or any other active component in the composition.
A kit, said kit comprising a first compartment containing an injectable composition comprising an aqueous solution of dalfopristine and quinupristine, and a second compartment containing an additive effective to avoid or reduce intolerance effects at the site of injection.
Dependencies are inferred from the claim text.