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US 6,187,743 B1Granted
Composition and method for enhancing wound healing
AssigneeDeRoyal Industries, Inc.
InventorEliot T. Obi-Tabot
Life of this patent
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AssigneeDeRoyal Industries, Inc.
InventorEliot T. Obi-Tabot
Estimating the term…
The healing of wounds is enhanced by contacting the wound surfaces with a dressing of D-glucose polysaccharide obtained by hydrolysis of starch containing ascorbic acid, collagen type I and alpha-tocopherol acetate. The collagen type I, and the ascorbic acid in the dressing are the typical chemotactic agents of neutrophils, fibroblasts and/or endothelial cells. These combinations can be present in the dressing as a gel. The composition material can be applied to the wound as a particulate material such as a powder, or as material such as a gel, paste, dispersion, solution or syrup. Wounds, in particular those occurring in the skin as second and third degree burns, stasis ulcers, trophic lesions, such as decubitus ulcers, severe cuts and abrasions which are commonly resistant to the natural healing process, may be treated with this composition. The application of this combination to open wounds greatly accelerates the rate of healing and reduces scarring. The invention includes an article useful in the therapy for surface wounds comprising the suspension of particles on non-adherent gauze and a bandage tape.
A method for promoting healing of a skin wound, comprising the steps of:
A method for promoting the healing of a skin wound, comprising the steps of:
A method of treating a skin wound which comprises the steps of applying to the wound an amount of starch hydrolysate having a DE of less than about 35 effective to form a film over said wound, the starch hydrolysate having a descriptive ratio of about 2.
A method for promoting healing of a surface wound, which method comprises applying to the wound a suspension including starch hydrolysate having a low dextrose equivalent DE, bovine collagen, alpha-tocopherol, and a minor amount of vitamin C, the collagen being chemotactic for fibroblasts or endothelial cells, wherein the suspension is applied repeatedly to the wound during the healing to effectively promote the healing process.
A composition for use in promoting healing of a surface wound, comprising an aqueous suspension of starch hydrolysate having a DE of less than 35, purified bovine collagen type I which has been treated to remove extraneous proteinaceous material, and alpha-tocopherol, wherein the amount of alpha-tocopherol is below that which produces an inhibition of migration of cells into a wound area, and is below that which produces undesirable local inflammation.
A composition for use in promoting healing of a surface wound, comprising a liquid aqueous suspension of a bovine collagen type I in admixture with a starch hydrolysate with a DE of less than 35 that exhibits a chemotactic effect on fibroblasts or endothelial cells, wherein the collagen is purified from a human placenta, and the collagen is present in the suspension at a concentration of about 0.2 to 2 μg/cm2.
A composition for use in promoting healing of a surface wound, comprising a liquid aqueous suspension of vitamin E and collagen type I, in admixture with a starch hydrolysate with a DE less than 35 that exhibits a chemotactic effect on fibroblasts or endothelial cells, wherein the collagen is in the suspension at a concentration of 2 μg/cm2.
A composition for use in promoting healing of a surface wound, comprising agents that greatly accelerate the rate of wound healing and reduce scarring, comprising of a liquid aqueous suspension of collagen in the order of 0.2-2 μg/cm2, Maltodextrin, NF as in admixture with a starch hydrolysate having a DE less than 35, and alpha-tocopherol in the order of 8-10 μg/ml in the suspension.
Dependencies are inferred from the claim text.