Back to results
US 6,187,594 B1Granted
Method and diagnostic agent for hemostasis diagnosis
AssigneeDade Behring Marburg GmbH
InventorsMichael Kraus, Carsten Schelp, Andreas Wiegand
Life of this patent
Estimating the term…
Abstract
The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
Claims55
A method for detecting a disturbance of hemostasis, comprising:
- 1) providing
- A) a sample to be tested and
- B) at least two primary substances which can enter into interaction with each other when in spatial proximity,
- wherein the interaction directly or indirectly provides a signal which correlates with the extent of interaction between said primary substances, and
- wherein at least one of the at least two primary substances is able to bind nonspecifically to components of a blood clot,
- 2) measuring the signal, and
- 3) correlating the signal with the degree of platelet aggregation, clot formation and/or clot dissolution in the sample.
4 more elements
A method for detecting clot formation or dissolution comprising:
- 1) providing a sample to be tested, a photosensitizer, and a chemiluminescent compound;
- wherein the photosensitizer and the chemiluminescent compound are brought into close proximity due to clot formation;
- and
- wherein the chemiluminescent compound is activated by singlet oxygen;
- and
- wherein at least one of the photosensitizer or the chemiluminescent compound is able to bind nonspecifically to components of a blood clot;
- 2) activating the photosensitizer to generate singlet oxygen;
- 3) detecting a signal related to the activation of the chemiluminescent compound by the singlet oxygen;
- and
- 4) correlating the signal to the degree of clot formation or dissolution in the sample.
7 more elements
A method for detecting clot formation or dissolution comprising:
- 1) providing a sample to be tested and at least two primary substances which can enter into interaction with each other when in close proximity,
- wherein said interaction produces a signal;
- wherein the at least two primary substances are brought into close proximity due to clot formation;
- and
- wherein formation of a clot brings the at least two primary substances into spatial proximity;
- and
- wherein at least one of the at least two primary substances is able to bind nonspecifically to components of a blood clot;
- 2) measuring a signal produced by the interaction of the at least two primary substances;
- and
- 3) correlating the signal to the degree of clot formation or dissolution in the sample.
7 more elements
Dependencies are inferred from the claim text.